| 8/28/2021 | Connecticut | 0 | at | Fresno State | 45 | @ MW | ||
| UTEP | 30 | at | New Mexico State | 3 | CUSA | |||
| 9/4/2021 | BYU | 24 | vs | Arizona | 16 | Las Vegas NV | vs P12 | |
| Holy Cross | 38 | at | Connecticut | 28 | Pat (1AA) | |||
| Army | 43 | at | Georgia State | 10 | @ SBC | |||
| Campbell | 7 | at | Liberty | 48 | BigS (1AA) | |||
| Massachusetts | 7 | at | Pittsburgh | 51 | @ ACC | |||
| New Mexico State | 10 | vs | San Diego State | 28 | Carson CA | vs MW | ||
| 9/11/2021 | Western Kentucky | 35 | at | Army | 38 | CUSA | ||
| Utah | 17 | at | BYU | 26 | P12 | |||
| Purdue | 49 | at | Connecticut | 0 | B10 | |||
| Boston College | 45 | at | Massachusetts | 28 | ACC | |||
| New Mexico State | 25 | at | New Mexico | 34 | @ MW | |||
| Liberty | 21 | at | Troy | 13 | @ SBC | |||
| 9/18/2021 | Connecticut | 21 | at | Army | 52 | |||
| Arizona State | 17 | at | BYU | 27 | P12 | |||
| Old Dominion | 17 | at | Liberty | 45 | CUSA | |||
| Eastern Michigan | 42 | at | Massachusetts | 28 | MAC | |||
| South Carolina State | 35 | at | New Mexico State | 43 | MEAC (1AA) | |||
| 9/24/2021 | Liberty | 21 | at | Syracuse | 24 | @ ACC | ||
| 9/25/2021 | Miami-Ohio | 10 | at | Army | 23 | MAC | ||
| South Florida | 27 | at | BYU | 35 | AAC | |||
| Massachusetts | 3 | at | Coastal Carolina | 53 | @ SBC | |||
| Wyoming | 24 | at | Connecticut | 22 | MW | |||
| Hawaii | 41 | at | New Mexico State | 21 | MW | |||
| 10/1/2021 | BYU | 34 | at | Utah State | 20 | @ MW | ||
| 10/2/2021 | Liberty | 36 | at | UAB | 12 | @ CUSA | ||
| Army | 16 | at | Ball State | 28 | @ MAC | |||
| Toledo | 45 | at | Massachusetts | 7 | MAC | |||
| New Mexico State | 31 | at | San Jose State | 37 | @ MW | |||
| Connecticut | 28 | at | Vanderbilt | 30 | @ SEC | |||
| 10/9/2021 | Boise State | 26 | at | BYU | 17 | MW | ||
| Middle Tenn State | 13 | at | Liberty | 41 | CUSA | |||
| Connecticut | 13 | at | Massachusetts | 27 | ||||
| New Mexico State | 28 | at | Nevada | 55 | @ MW | |||
| 10/16/2021 | BYU | 24 | at | Baylor | 38 | @ B12 | ||
| Yale | 15 | at | Connecticut | 21 | Ivy (1AA) | |||
| Liberty | 28 | at | UL Monroe | 31 | @ SBC | |||
| Army | 14 | at | Wisconsin | 20 | @ B10 | |||
| 10/22/2021 | Middle Tenn State | 44 | at | Connecticut | 13 | CUSA | ||
| 10/23/2021 | Wake Forest | 70 | at | Army | 56 | ACC | ||
| Massachusetts | 3 | at | Florida State | 59 | @ ACC | |||
| New Mexico State | 34 | at | Hawaii | 48 | @ MW | |||
| Liberty | 35 | at | North Texas | 26 | @ CUSA | |||
| BYU | 21 | at | Washington State | 19 | @ P12 | |||
| 10/30/2021 | Virginia | 49 | at | BYU | 66 | ACC | ||
| Massachusetts | 17 | at | Liberty | 62 | ||||
| 11/6/2021 | Army | 21 | vs | Air Force | 14 | OT | Arlington TX | vs MW |
| Idaho State | 14 | at | BYU | 59 | BSky (1AA) | |||
| Rhode Island | 35 | at | Massachusetts | 22 | CAAF (1AA) | |||
| Liberty | 14 | at | Mississippi | 27 | @ SEC | |||
| Utah State | 35 | at | New Mexico State | 13 | MW | |||
| 11/13/2021 | New Mexico State | 3 | at | Alabama | 59 | @ SEC | ||
| Bucknell | 10 | at | Army | 63 | Pat (1AA) | |||
| Connecticut | 7 | at | Clemson | 44 | @ ACC | |||
| Maine | 35 | at | Massachusetts | 10 | CAAF (1AA) | |||
| 11/20/2021 | Massachusetts | 17 | at | Army | 33 | |||
| Connecticut | 17 | at | UCF | 49 | @ AAC | |||
| BYU | 34 | at | Georgia Southern | 17 | @ SBC | |||
| New Mexico State | 16 | at | Kentucky | 56 | @ SEC | |||
| UL Lafayette | 42 | at | Liberty | 14 | SBC | |||
| 11/27/2021 | Houston | 45 | at | Connecticut | 17 | AAC | ||
| Army | 31 | at | Liberty | 16 | ||||
| Massachusetts | 27 | at | New Mexico State | 44 | ||||
| BYU | 35 | at | Southern California | 31 | @ P12 | |||
| 12/11/2021 | Army | 13 | vs | Navy | 17 | East Rutherford NJ | vs AAC | |
| 12/18/2021 | UAB | 31 | vs | BYU | 28 | Independence Bowl - Shreveport LA | vs CUSA | |
| Eastern Michigan | 20 | vs | Liberty | 56 | Lending Tree Bowl - Mobile AL | vs MAC | ||
| 12/22/2021 | Missouri | 22 | vs | Army | 24 | Armed Forces Bowl - Fort Worth TX | vs SEC |