| 9/2/2021 | The Citadel (4-7) | 14 | at | Coastal Carolina | 52 | SoCon (1AA) | ||
| 9/10/2021 | Kansas (2-10) | 22 | at | Coastal Carolina | 49 | B12 | ||
| 9/18/2021 | Coastal Carolina | 28 | at | Buffalo (4-8) | 25 | at MAC | ||
| 9/25/2021 | Massachusetts (1-11) | 3 | at | Coastal Carolina | 53 | Ind | ||
| 10/2/2021 | UL Monroe (4-8,2-6) | 6 | at | Coastal Carolina | 59 | |||
| 10/7/2021 | Coastal Carolina | 52 | at | Arkansas State (2-10,1-7) | 20 | |||
| 10/20/2021 | Coastal Carolina | 27 | at | Appalachian State (10-4,7-2) | 30 | |||
| 10/28/2021 | Troy (5-7,3-5) | 28 | at | Coastal Carolina | 35 | |||
| 11/6/2021 | Coastal Carolina | 28 | at | Georgia Southern (3-9,2-6) | 8 | |||
| 11/13/2021 | Georgia State (8-5,6-2) | 42 | at | Coastal Carolina | 40 | |||
| 11/20/2021 | Texas State (4-8,3-5) | 21 | at | Coastal Carolina | 35 | |||
| 11/26/2021 | Coastal Carolina | 27 | at | South Alabama (5-7,2-6) | 21 | OT | ||
| 12/17/2021 | Northern Illinois (9-5) | 41 | vs | Coastal Carolina | 47 | Tangerine Cure Bowl - Orlando FL | MAC |
| vs Coastal Carolina | vs Other Opponents | Coastal Carolina compared to OOs | |
| Record: | 2-11 | 59-88 | |
| Points Scored: | 21.62 | 25.39 | 3.77 |
| Points Allowed: | 40.92 | 31.50 | 9.42 |
| Margin: | -19.30 | -6.11 | 13.19 |
| Total Points: | 62.54 | 56.89 | 5.65 |