| 8/28/2021 | Southern Utah (1-10) | 14 | at | San Jose State | 45 | BSky (1AA) | ||
| 9/4/2021 | San Jose State | 7 | at | Southern California (4-8) | 30 | at P12 | ||
| 9/18/2021 | San Jose State | 17 | at | Hawaii (6-7,3-5) | 13 | |||
| 9/25/2021 | San Jose State | 3 | at | Western Michigan (8-5) | 23 | at MAC | ||
| 10/2/2021 | New Mexico State (2-10) | 31 | at | San Jose State | 37 | Ind | ||
| 10/9/2021 | San Jose State | 14 | at | Colorado State (3-9,2-6) | 32 | |||
| 10/15/2021 | San Diego State (12-2,7-2) | 19 | at | San Jose State | 13 | 2OT | ||
| 10/21/2021 | San Jose State | 27 | at | UNLV (2-10,2-6) | 20 | |||
| 10/30/2021 | Wyoming (7-6,2-6) | 21 | at | San Jose State | 27 | |||
| 11/6/2021 | San Jose State | 24 | at | Nevada (8-5,5-3) | 27 | |||
| 11/13/2021 | Utah State (11-3,7-2) | 48 | at | San Jose State | 17 | |||
| 11/25/2021 | Fresno State (10-3,6-2) | 40 | at | San Jose State | 9 |
| vs San Jose State | vs Other Opponents | San Jose State compared to OOs | |
| Record: | 7-5 | 67-73 | |
| Points Scored: | 26.50 | 27.87 | 1.37 |
| Points Allowed: | 20.00 | 29.32 | -9.32 |
| Margin: | 6.50 | -1.45 | -7.95 |
| Total Points: | 46.50 | 57.19 | -10.69 |