| 9/6/2021 | Louisville (6-7) | 24 | vs | Mississippi | 43 | Atlanta GA | ACC | |
| 9/11/2021 | Austin Peay (6-5) | 17 | at | Mississippi | 54 | OVC (1AA) | ||
| 9/18/2021 | Tulane (2-10) | 21 | at | Mississippi | 61 | AAC | ||
| 10/2/2021 | Mississippi | 21 | at | Alabama (13-2,8-2) | 42 | |||
| 10/9/2021 | Arkansas (9-4,4-4) | 51 | at | Mississippi | 52 | |||
| 10/16/2021 | Mississippi | 31 | at | Tennessee (7-6,4-4) | 26 | |||
| 10/23/2021 | LSU (6-7,3-5) | 17 | at | Mississippi | 31 | |||
| 10/30/2021 | Mississippi | 20 | at | Auburn (6-7,3-5) | 31 | |||
| 11/6/2021 | Liberty (8-5) | 14 | at | Mississippi | 27 | Ind | ||
| 11/13/2021 | Texas A&M (8-4,4-4) | 19 | at | Mississippi | 29 | |||
| 11/20/2021 | Vanderbilt (2-10,0-8) | 17 | at | Mississippi | 31 | |||
| 11/25/2021 | Mississippi | 31 | at | Mississippi State (7-6,4-4) | 21 | |||
| 1/1/2022 | Baylor (12-2) | 21 | vs | Mississippi | 7 | Sugar Bowl - New Orleans LA | B12 |
| vs Mississippi | vs Other Opponents | Mississippi compared to OOs | |
| Record: | 3-10 | 89-65 | |
| Points Scored: | 24.69 | 31.18 | 6.49 |
| Points Allowed: | 33.69 | 24.03 | 9.66 |
| Margin: | -9.00 | 7.15 | 16.15 |
| Total Points: | 58.38 | 55.21 | 3.17 |