| 9/4/2021 | Syracuse | 29 | at | Ohio (3-9) | 9 | at MAC | ||
| 9/11/2021 | Rutgers (5-8) | 17 | at | Syracuse | 7 | B10 | ||
| 9/18/2021 | Albany NY (2-9) | 24 | at | Syracuse | 62 | CAAF (1AA) | ||
| 9/24/2021 | Liberty (8-5) | 21 | at | Syracuse | 24 | Ind | ||
| 10/2/2021 | Syracuse | 30 | at | Florida State (5-7,4-4) | 33 | |||
| 10/9/2021 | Wake Forest (11-3,7-3) | 40 | at | Syracuse | 37 | OT | ||
| 10/15/2021 | Clemson (10-3,6-2) | 17 | at | Syracuse | 14 | |||
| 10/23/2021 | Syracuse | 41 | at | Virginia Tech (6-7,4-4) | 36 | |||
| 10/30/2021 | Boston College (6-6,2-6) | 6 | at | Syracuse | 21 | |||
| 11/13/2021 | Syracuse | 3 | at | Louisville (6-7,4-4) | 41 | |||
| 11/20/2021 | Syracuse | 17 | at | North Carolina State (9-3,6-2) | 41 | |||
| 11/27/2021 | Pittsburgh (11-3,8-1) | 31 | at | Syracuse | 14 |
| vs Syracuse | vs Other Opponents | Syracuse compared to OOs | |
| Record: | 7-5 | 75-65 | |
| Points Scored: | 26.33 | 29.25 | 2.92 |
| Points Allowed: | 24.92 | 24.27 | 0.65 |
| Margin: | 1.41 | 4.98 | 3.57 |
| Total Points: | 51.25 | 53.52 | -2.27 |