| 9/4/2021 | Penn State (7-6,4-5) | 16 | at | Wisconsin | 10 | |||
| 9/11/2021 | Eastern Michigan (7-6) | 7 | at | Wisconsin | 34 | MAC | ||
| 9/25/2021 | Notre Dame (11-2) | 41 | vs | Wisconsin | 13 | Chicago IL | ND | |
| 10/2/2021 | Michigan (12-2,9-1) | 38 | at | Wisconsin | 17 | |||
| 10/9/2021 | Wisconsin | 24 | at | Illinois (5-7,4-5) | 0 | |||
| 10/16/2021 | Army (9-4) | 14 | at | Wisconsin | 20 | Ind | ||
| 10/23/2021 | Wisconsin | 30 | at | Purdue (9-4,6-3) | 13 | |||
| 10/30/2021 | Iowa (10-4,7-3) | 7 | at | Wisconsin | 27 | |||
| 11/6/2021 | Wisconsin | 52 | at | Rutgers (5-8,2-7) | 3 | |||
| 11/13/2021 | Northwestern (3-9,1-8) | 7 | at | Wisconsin | 35 | |||
| 11/20/2021 | Nebraska (3-9,1-8) | 28 | at | Wisconsin | 35 | |||
| 11/27/2021 | Wisconsin | 13 | at | Minnesota (9-4,6-3) | 23 | |||
| 12/30/2021 | Wisconsin | 20 | vs | Arizona State (8-5) | 13 | Las Vegas Bowl - Las Vegas NV | vs P12 |
| vs Wisconsin | vs Other Opponents | Wisconsin compared to OOs | |
| Record: | 4-9 | 94-61 | |
| Points Scored: | 16.15 | 27.94 | 11.79 |
| Points Allowed: | 25.38 | 21.59 | 3.79 |
| Margin: | -9.23 | 6.35 | 15.58 |
| Total Points: | 41.53 | 49.53 | -8.00 |