| 9/5/2021 | Notre Dame (11-2) | 41 | at | Florida State | 38 | OT | ND | |
| 9/11/2021 | Jacksonville State (5-6) | 20 | at | Florida State | 17 | WAC (1AA) | ||
| 9/18/2021 | Florida State | 14 | at | Wake Forest (11-3,7-3) | 35 | |||
| 9/25/2021 | Louisville (6-7,4-4) | 31 | at | Florida State | 23 | |||
| 10/2/2021 | Syracuse (5-7,2-6) | 30 | at | Florida State | 33 | |||
| 10/9/2021 | Florida State | 35 | at | North Carolina (6-7,4-5) | 25 | |||
| 10/23/2021 | Massachusetts (1-11) | 3 | at | Florida State | 59 | Ind | ||
| 10/30/2021 | Florida State | 20 | at | Clemson (10-3,6-2) | 30 | |||
| 11/6/2021 | North Carolina State (9-3,6-2) | 28 | at | Florida State | 14 | |||
| 11/13/2021 | Miami-Florida (7-5,5-3) | 28 | at | Florida State | 31 | |||
| 11/20/2021 | Florida State | 26 | at | Boston College (6-6,2-6) | 23 | |||
| 11/27/2021 | Florida State | 21 | at | Florida (6-7) | 24 | at SEC |
| vs Florida State | vs Other Opponents | Florida State compared to OOs | |
| Record: | 7-5 | 76-62 | |
| Points Scored: | 26.50 | 30.17 | 3.67 |
| Points Allowed: | 27.58 | 26.30 | 1.28 |
| Margin: | -1.08 | 3.87 | 4.95 |
| Total Points: | 54.08 | 56.47 | -2.39 |