| 9/4/2021 | Colgate (5-6) | 0 | at | Boston College | 51 | Pat (1AA) | ||
| 9/11/2021 | Boston College | 45 | at | Massachusetts (1-11) | 28 | at Ind | ||
| 9/18/2021 | Boston College | 28 | at | Temple (3-9) | 3 | at AAC | ||
| 9/25/2021 | Missouri (6-7) | 34 | at | Boston College | 41 | OT | SEC | |
| 10/2/2021 | Boston College | 13 | at | Clemson (10-3,6-2) | 19 | |||
| 10/16/2021 | North Carolina State (9-3,6-2) | 33 | at | Boston College | 7 | |||
| 10/23/2021 | Boston College | 14 | at | Louisville (6-7,4-4) | 28 | |||
| 10/30/2021 | Boston College | 6 | at | Syracuse (5-7,2-6) | 21 | |||
| 11/5/2021 | Virginia Tech (6-7,4-4) | 3 | at | Boston College | 17 | |||
| 11/13/2021 | Boston College | 41 | at | Georgia Tech (3-9,2-6) | 30 | |||
| 11/20/2021 | Florida State (5-7,4-4) | 26 | at | Boston College | 23 | |||
| 11/27/2021 | Wake Forest (11-3,7-3) | 41 | at | Boston College | 10 | |||
| 12/27/2021 | Boston College | vs | East Carolina (7-5) | Cancelled Military Bowl - Annapolis MD | vs AAC |
| vs Boston College | vs Other Opponents | Boston College compared to OOs | |
| Record: | 6-6 | 71-78 | |
| Points Scored: | 22.17 | 26.95 | 4.78 |
| Points Allowed: | 24.67 | 28.63 | -3.96 |
| Margin: | -2.50 | -1.68 | 0.82 |
| Total Points: | 46.84 | 55.58 | -8.74 |