| 9/2/2021 | Houston Baptist (0-11) | 17 | at | New Mexico | 27 | SLC (1AA) | ||
| 9/11/2021 | New Mexico State (2-10) | 25 | at | New Mexico | 34 | Ind | ||
| 9/18/2021 | New Mexico | 0 | at | Texas A&M (8-4) | 34 | at SEC | ||
| 9/25/2021 | New Mexico | 13 | at | UTEP (7-6) | 20 | at CUSA | ||
| 10/2/2021 | Air Force (10-3,6-2) | 38 | at | New Mexico | 10 | |||
| 10/9/2021 | New Mexico | 7 | vs | San Diego State (12-2,7-2) | 31 | Carson CA | ||
| 10/16/2021 | Colorado State (3-9,2-6) | 36 | at | New Mexico | 7 | |||
| 10/23/2021 | New Mexico | 14 | at | Wyoming (7-6,2-6) | 3 | |||
| 11/6/2021 | UNLV (2-10,2-6) | 31 | at | New Mexico | 17 | |||
| 11/13/2021 | New Mexico | 7 | at | Fresno State (10-3,6-2) | 34 | |||
| 11/20/2021 | New Mexico | 0 | at | Boise State (7-5,5-3) | 37 | |||
| 11/26/2021 | Utah State (11-3,7-2) | 35 | at | New Mexico | 10 |
| vs New Mexico | vs Other Opponents | New Mexico compared to OOs | |
| Record: | 9-3 | 70-69 | |
| Points Scored: | 28.42 | 26.53 | -1.89 |
| Points Allowed: | 12.17 | 26.83 | -14.66 |
| Margin: | 16.25 | -0.30 | -16.55 |
| Total Points: | 40.59 | 53.36 | -12.77 |