| 9/2/2021 | Southern Utah (1-10) | 14 | at | Arizona State | 41 | BSky (1AA) | ||
| 9/11/2021 | UNLV (2-10) | 10 | at | Arizona State | 37 | MW | ||
| 9/18/2021 | Arizona State | 17 | at | BYU (10-3) | 27 | at Ind | ||
| 9/25/2021 | Colorado (4-8,3-6) | 13 | at | Arizona State | 35 | |||
| 10/2/2021 | Arizona State | 42 | at | UCLA (8-4,6-3) | 23 | |||
| 10/8/2021 | Stanford (3-9,2-7) | 10 | at | Arizona State | 28 | |||
| 10/16/2021 | Arizona State | 21 | at | Utah (10-4,9-1) | 35 | |||
| 10/30/2021 | Washington State (7-6,6-3) | 34 | at | Arizona State | 21 | |||
| 11/6/2021 | Southern California (4-8,3-6) | 16 | at | Arizona State | 31 | |||
| 11/13/2021 | Arizona State | 35 | at | Washington (4-8,3-6) | 30 | |||
| 11/20/2021 | Arizona State | 10 | at | Oregon State (7-6,5-4) | 24 | |||
| 11/27/2021 | Arizona (1-11,1-8) | 15 | at | Arizona State | 38 | |||
| 12/30/2021 | Wisconsin (9-4) | 20 | vs | Arizona State | 13 | Las Vegas Bowl - Las Vegas NV | B10 |
| vs Arizona State | vs Other Opponents | Arizona State compared to OOs | |
| Record: | 5-8 | 65-83 | |
| Points Scored: | 20.85 | 26.60 | 5.75 |
| Points Allowed: | 28.38 | 27.13 | 1.25 |
| Margin: | -7.53 | -0.53 | 7.00 |
| Total Points: | 49.23 | 53.73 | -4.50 |