| 9/2/2021 | Boise State (7-5) | 31 | at | UCF | 36 | MW | ||
| 9/11/2021 | Bethune-Cookman (2-9) | 14 | at | UCF | 63 | SWAC (1AA) | ||
| 9/17/2021 | UCF | 35 | at | Louisville (6-7) | 42 | at ACC | ||
| 10/2/2021 | UCF | 30 | at | Navy (4-8,3-5) | 34 | |||
| 10/9/2021 | East Carolina (7-5,5-3) | 16 | at | UCF | 20 | |||
| 10/16/2021 | UCF | 21 | at | Cincinnati (13-1,9-0) | 56 | |||
| 10/22/2021 | Memphis (6-6,3-5) | 7 | at | UCF | 24 | |||
| 10/30/2021 | UCF | 49 | at | Temple (3-9,1-7) | 7 | |||
| 11/6/2021 | Tulane (2-10,1-7) | 10 | at | UCF | 14 | |||
| 11/13/2021 | UCF | 28 | at | SMU (8-4,4-4) | 55 | |||
| 11/20/2021 | Connecticut (1-11) | 17 | at | UCF | 49 | Ind | ||
| 11/26/2021 | South Florida (2-10,1-7) | 13 | at | UCF | 17 | |||
| 12/23/2021 | UCF | 29 | vs | Florida (6-7) | 17 | Gasparilla Bowl - Saint Petersburg FL | vs SEC |
| vs UCF | vs Other Opponents | UCF compared to OOs | |
| Record: | 4-9 | 63-83 | |
| Points Scored: | 24.54 | 27.66 | 3.12 |
| Points Allowed: | 31.92 | 28.99 | 2.93 |
| Margin: | -7.38 | -1.33 | 6.05 |
| Total Points: | 56.46 | 56.65 | -0.19 |