| 9/4/2021 | Miami-Ohio | 14 | at | Cincinnati (13-1) | 49 | at AAC | ||
| 9/11/2021 | Miami-Ohio | 26 | at | Minnesota (9-4) | 31 | at B10 | ||
| 9/18/2021 | LIU (2-8) | 7 | at | Miami-Ohio | 42 | NE (1AA) | ||
| 9/25/2021 | Miami-Ohio | 10 | at | Army (9-4) | 23 | at Ind | ||
| 10/2/2021 | Central Michigan (9-4,6-2) | 17 | at | Miami-Ohio | 28 | |||
| 10/9/2021 | Miami-Ohio | 12 | at | Eastern Michigan (7-6,4-4) | 13 | |||
| 10/16/2021 | Akron (2-10,1-7) | 21 | at | Miami-Ohio | 34 | |||
| 10/23/2021 | Miami-Ohio | 24 | at | Ball State (6-7,4-4) | 17 | |||
| 11/2/2021 | Miami-Ohio | 33 | at | Ohio (3-9,3-5) | 35 | |||
| 11/9/2021 | Buffalo (4-8,2-6) | 18 | at | Miami-Ohio | 45 | |||
| 11/16/2021 | Bowling Green (4-8,2-6) | 7 | at | Miami-Ohio | 34 | |||
| 11/27/2021 | Miami-Ohio | 47 | at | Kent State (7-7,6-3) | 48 | OT | ||
| 12/23/2021 | North Texas (6-7) | 14 | vs | Miami-Ohio | 27 | Frisco Football Classic - Frisco TX | CUSA |
| vs Miami-Ohio | vs Other Opponents | Miami-Ohio compared to OOs | |
| Record: | 6-7 | 75-76 | |
| Points Scored: | 23.08 | 27.64 | 4.56 |
| Points Allowed: | 28.92 | 28.50 | 0.42 |
| Margin: | -5.84 | -0.86 | 4.98 |
| Total Points: | 52.00 | 56.14 | -4.14 |