| 9/4/2021 | Central Michigan (9-4) | 24 | at | Missouri | 34 | MAC | ||
| 9/11/2021 | Missouri | 28 | at | Kentucky (10-3,5-3) | 35 | |||
| 9/18/2021 | SE Missouri State (4-7) | 28 | at | Missouri | 59 | OVC (1AA) | ||
| 9/25/2021 | Missouri | 34 | at | Boston College (6-6) | 41 | OT | at ACC | |
| 10/2/2021 | Tennessee (7-6,4-4) | 62 | at | Missouri | 24 | |||
| 10/9/2021 | North Texas (6-7) | 35 | at | Missouri | 48 | CUSA | ||
| 10/16/2021 | Texas A&M (8-4,4-4) | 35 | at | Missouri | 14 | |||
| 10/30/2021 | Missouri | 37 | at | Vanderbilt (2-10,0-8) | 28 | |||
| 11/6/2021 | Missouri | 6 | at | Georgia (14-1,9-1) | 43 | |||
| 11/13/2021 | South Carolina (7-6,3-5) | 28 | at | Missouri | 31 | |||
| 11/20/2021 | Florida (6-7,2-6) | 23 | at | Missouri | 24 | OT | ||
| 11/26/2021 | Missouri | 17 | at | Arkansas (9-4,4-4) | 34 | |||
| 12/22/2021 | Missouri | 22 | vs | Army (9-4) | 24 | Armed Forces Bowl - Fort Worth TX | vs Ind |
| vs Missouri | vs Other Opponents | Missouri compared to OOs | |
| Record: | 7-6 | 90-63 | |
| Points Scored: | 33.85 | 29.43 | -4.42 |
| Points Allowed: | 29.08 | 23.55 | 5.53 |
| Margin: | 4.77 | 5.88 | 1.11 |
| Total Points: | 62.93 | 52.98 | 9.95 |