| 9/4/2021 | East Tennessee St (11-2) | 23 | at | Vanderbilt | 3 | SoCon (1AA) | ||
| 9/11/2021 | Vanderbilt | 24 | at | Colorado State (3-9) | 21 | at MW | ||
| 9/18/2021 | Stanford (3-9) | 41 | at | Vanderbilt | 23 | P12 | ||
| 9/25/2021 | Georgia (14-1,9-1) | 62 | at | Vanderbilt | 0 | |||
| 10/2/2021 | Connecticut (1-11) | 28 | at | Vanderbilt | 30 | Ind | ||
| 10/9/2021 | Vanderbilt | 0 | at | Florida (6-7,2-6) | 42 | |||
| 10/16/2021 | Vanderbilt | 20 | at | South Carolina (7-6,3-5) | 21 | |||
| 10/23/2021 | Mississippi State (7-6,4-4) | 45 | at | Vanderbilt | 6 | |||
| 10/30/2021 | Missouri (6-7,3-5) | 37 | at | Vanderbilt | 28 | |||
| 11/13/2021 | Kentucky (10-3,5-3) | 34 | at | Vanderbilt | 17 | |||
| 11/20/2021 | Vanderbilt | 17 | at | Mississippi (10-3,6-2) | 31 | |||
| 11/27/2021 | Vanderbilt | 21 | at | Tennessee (7-6,4-4) | 45 |
| vs Vanderbilt | vs Other Opponents | Vanderbilt compared to OOs | |
| Record: | 10-2 | 75-68 | |
| Points Scored: | 35.83 | 28.73 | -7.10 |
| Points Allowed: | 15.75 | 27.04 | -11.29 |
| Margin: | 20.08 | 1.69 | -18.39 |
| Total Points: | 51.58 | 55.77 | -4.19 |