| 9/4/2021 | Northwestern State (3-8) | 14 | at | North Texas | 44 | SLC (1AA) | ||
| 9/11/2021 | North Texas | 12 | at | SMU (8-4) | 35 | at AAC | ||
| 9/18/2021 | UAB (9-4,6-2) | 40 | at | North Texas | 6 | |||
| 9/25/2021 | North Texas | 17 | at | Louisiana Tech (3-9,2-6) | 24 | |||
| 10/9/2021 | North Texas | 35 | at | Missouri (6-7) | 48 | at SEC | ||
| 10/15/2021 | Marshall (7-6,5-3) | 49 | at | North Texas | 21 | |||
| 10/23/2021 | Liberty (8-5) | 35 | at | North Texas | 26 | Ind | ||
| 10/30/2021 | North Texas | 30 | at | Rice (4-8,3-5) | 24 | OT | ||
| 11/6/2021 | North Texas | 38 | at | Southern Miss (3-9,2-6) | 14 | |||
| 11/13/2021 | UTEP (7-6,4-4) | 17 | at | North Texas | 20 | |||
| 11/20/2021 | North Texas | 49 | at | Florida Intl (1-11,0-8) | 7 | |||
| 11/27/2021 | Texas-San Antonio (12-2,8-1) | 23 | at | North Texas | 45 | |||
| 12/23/2021 | North Texas | 14 | vs | Miami-Ohio (7-6) | 27 | Frisco Football Classic - Frisco TX | vs MAC |
| vs North Texas | vs Other Opponents | North Texas compared to OOs | |
| Record: | 7-6 | 71-79 | |
| Points Scored: | 27.46 | 28.09 | 0.63 |
| Points Allowed: | 27.46 | 28.77 | -1.31 |
| Margin: | 0.00 | -0.68 | -0.68 |
| Total Points: | 54.92 | 56.86 | -1.94 |