| 9/4/2021 | Nevada | 22 | at | California (5-7) | 17 | at P12 | ||
| 9/11/2021 | Idaho State (1-10) | 10 | at | Nevada | 49 | BSky (1AA) | ||
| 9/18/2021 | Nevada | 17 | at | Kansas State (8-5) | 38 | at B12 | ||
| 10/2/2021 | Nevada | 41 | at | Boise State (7-5,5-3) | 31 | |||
| 10/9/2021 | New Mexico State (2-10) | 28 | at | Nevada | 55 | Ind | ||
| 10/16/2021 | Hawaii (6-7,3-5) | 17 | at | Nevada | 34 | |||
| 10/23/2021 | Nevada | 32 | at | Fresno State (10-3,6-2) | 34 | |||
| 10/29/2021 | UNLV (2-10,2-6) | 20 | at | Nevada | 51 | |||
| 11/6/2021 | San Jose State (5-7,3-5) | 24 | at | Nevada | 27 | |||
| 11/13/2021 | Nevada | 21 | vs | San Diego State (12-2,7-2) | 23 | Carson CA | ||
| 11/19/2021 | Air Force (10-3,6-2) | 41 | at | Nevada | 39 | 3OT | ||
| 11/27/2021 | Nevada | 52 | at | Colorado State (3-9,2-6) | 10 | |||
| 12/27/2021 | Western Michigan (8-5) | 52 | vs | Nevada | 24 | Quick Lane Bowl - Detroit MI | MAC |
| vs Nevada | vs Other Opponents | Nevada compared to OOs | |
| Record: | 5-8 | 74-75 | |
| Points Scored: | 26.54 | 26.01 | -0.53 |
| Points Allowed: | 35.69 | 25.44 | 10.25 |
| Margin: | -9.15 | 0.57 | 9.72 |
| Total Points: | 62.23 | 51.45 | 10.78 |