| 9/1/2021 | UAB | 31 | vs | Jacksonville State (5-6) | 0 | Montgomery AL | vs WAC | |
| 9/11/2021 | UAB | 7 | at | Georgia (14-1) | 56 | at SEC | ||
| 9/18/2021 | UAB | 40 | at | North Texas (6-7,5-3) | 6 | |||
| 9/25/2021 | UAB | 28 | at | Tulane (2-10) | 21 | at AAC | ||
| 10/2/2021 | Liberty (8-5) | 36 | at | UAB | 12 | Ind | ||
| 10/9/2021 | Florida Atlantic (5-7,3-5) | 14 | at | UAB | 31 | |||
| 10/16/2021 | UAB | 34 | at | Southern Miss (3-9,2-6) | 0 | |||
| 10/23/2021 | Rice (4-8,3-5) | 30 | at | UAB | 24 | |||
| 11/6/2021 | Louisiana Tech (3-9,2-6) | 38 | at | UAB | 52 | |||
| 11/13/2021 | UAB | 21 | at | Marshall (7-6,5-3) | 14 | |||
| 11/20/2021 | UAB | 31 | at | Texas-San Antonio (12-2,8-1) | 34 | |||
| 11/26/2021 | UTEP (7-6,4-4) | 25 | at | UAB | 42 | |||
| 12/18/2021 | UAB | 31 | vs | BYU (10-3) | 28 | Independence Bowl - Shreveport LA | vs Ind |
| vs UAB | vs Other Opponents | UAB compared to OOs | |
| Record: | 4-9 | 82-70 | |
| Points Scored: | 23.23 | 29.32 | 6.09 |
| Points Allowed: | 29.54 | 25.76 | 3.78 |
| Margin: | -6.31 | 3.56 | 9.87 |
| Total Points: | 52.77 | 55.08 | -2.31 |