| 9/4/2021 | William & Mary (6-5) | 0 | at | Virginia | 43 | CAAF (1AA) | ||
| 9/11/2021 | Illinois (5-7) | 14 | at | Virginia | 42 | B10 | ||
| 9/18/2021 | Virginia | 39 | at | North Carolina (6-7,4-5) | 59 | |||
| 9/24/2021 | Wake Forest (11-3,7-3) | 37 | at | Virginia | 17 | |||
| 9/30/2021 | Virginia | 30 | at | Miami-Florida (7-5,5-3) | 28 | |||
| 10/9/2021 | Virginia | 34 | at | Louisville (6-7,4-4) | 33 | |||
| 10/16/2021 | Duke (3-9,0-8) | 0 | at | Virginia | 48 | |||
| 10/23/2021 | Georgia Tech (3-9,2-6) | 40 | at | Virginia | 48 | |||
| 10/30/2021 | Virginia | 49 | at | BYU (10-3) | 66 | at Ind | ||
| 11/13/2021 | Notre Dame (11-2) | 28 | at | Virginia | 3 | ND | ||
| 11/20/2021 | Virginia | 38 | at | Pittsburgh (11-3,8-1) | 48 | |||
| 11/27/2021 | Virginia Tech (6-7,4-4) | 29 | at | Virginia | 24 | |||
| 12/29/2021 | SMU (8-4) | vs | Virginia | Cancelled Wasabi Fenway Bowl - Boston MA | AAC |
| vs Virginia | vs Other Opponents | Virginia compared to OOs | |
| Record: | 6-6 | 87-65 | |
| Points Scored: | 31.83 | 31.29 | -0.54 |
| Points Allowed: | 34.58 | 26.75 | 7.83 |
| Margin: | -2.75 | 4.54 | 7.29 |
| Total Points: | 66.41 | 58.04 | 8.37 |