| 9/4/2021 | BYU (10-3) | 24 | vs | Arizona | 16 | Las Vegas NV | Ind | |
| 9/11/2021 | San Diego State (12-2) | 38 | at | Arizona | 14 | MW | ||
| 9/18/2021 | Northern Arizona (5-6) | 21 | at | Arizona | 19 | BSky (1AA) | ||
| 9/25/2021 | Arizona | 19 | at | Oregon (10-4,7-3) | 41 | |||
| 10/9/2021 | UCLA (8-4,6-3) | 34 | at | Arizona | 16 | |||
| 10/16/2021 | Arizona | 0 | at | Colorado (4-8,3-6) | 34 | |||
| 10/22/2021 | Washington (4-8,3-6) | 21 | at | Arizona | 16 | |||
| 10/30/2021 | Arizona | 34 | at | Southern California (4-8,3-6) | 41 | |||
| 11/6/2021 | California (5-7,4-5) | 3 | at | Arizona | 10 | |||
| 11/13/2021 | Utah (10-4,9-1) | 38 | at | Arizona | 29 | |||
| 11/19/2021 | Arizona | 18 | at | Washington State (7-6,6-3) | 44 | |||
| 11/27/2021 | Arizona | 15 | at | Arizona State (8-5,6-3) | 38 |
| vs Arizona | vs Other Opponents | Arizona compared to OOs | |
| Record: | 11-1 | 76-64 | |
| Points Scored: | 31.42 | 28.10 | -3.32 |
| Points Allowed: | 17.17 | 25.46 | -8.29 |
| Margin: | 14.25 | 2.64 | -11.61 |
| Total Points: | 48.59 | 53.56 | -4.97 |