| 9/4/2021 | UL Monroe (4-8) | 10 | at | Kentucky | 45 | SBC | ||
| 9/11/2021 | Missouri (6-7,3-5) | 28 | at | Kentucky | 35 | |||
| 9/18/2021 | Chattanooga (6-5) | 23 | at | Kentucky | 28 | SoCon (1AA) | ||
| 9/25/2021 | Kentucky | 16 | at | South Carolina (7-6,3-5) | 10 | |||
| 10/2/2021 | Florida (6-7,2-6) | 13 | at | Kentucky | 20 | |||
| 10/9/2021 | LSU (6-7,3-5) | 21 | at | Kentucky | 42 | |||
| 10/16/2021 | Kentucky | 13 | at | Georgia (14-1,9-1) | 30 | |||
| 10/30/2021 | Kentucky | 17 | at | Mississippi State (7-6,4-4) | 31 | |||
| 11/6/2021 | Tennessee (7-6,4-4) | 45 | at | Kentucky | 42 | |||
| 11/13/2021 | Kentucky | 34 | at | Vanderbilt (2-10,0-8) | 17 | |||
| 11/20/2021 | New Mexico State (2-10) | 16 | at | Kentucky | 56 | Ind | ||
| 11/27/2021 | Kentucky | 52 | at | Louisville (6-7) | 21 | at ACC | ||
| 1/1/2022 | Iowa (10-4) | 17 | vs | Kentucky | 20 | Citrus Bowl - Orlando FL | B10 |
| vs Kentucky | vs Other Opponents | Kentucky compared to OOs | |
| Record: | 3-10 | 80-74 | |
| Points Scored: | 21.69 | 28.21 | 6.52 |
| Points Allowed: | 32.31 | 26.12 | 6.19 |
| Margin: | -10.62 | 2.09 | 12.71 |
| Total Points: | 54.00 | 54.33 | -0.33 |