| 9/4/2021 | Utah State (11-3) | 26 | at | Washington State | 23 | MW | ||
| 9/11/2021 | Portland State (5-6) | 24 | at | Washington State | 44 | BSky (1AA) | ||
| 9/18/2021 | Southern California (4-8,3-6) | 45 | at | Washington State | 14 | |||
| 9/25/2021 | Washington State | 13 | at | Utah (10-4,9-1) | 24 | |||
| 10/2/2021 | Washington State | 21 | at | California (5-7,4-5) | 6 | |||
| 10/9/2021 | Oregon State (7-6,5-4) | 24 | at | Washington State | 31 | |||
| 10/16/2021 | Stanford (3-9,2-7) | 31 | at | Washington State | 34 | |||
| 10/23/2021 | BYU (10-3) | 21 | at | Washington State | 19 | Ind | ||
| 10/30/2021 | Washington State | 34 | at | Arizona State (8-5,6-3) | 21 | |||
| 11/13/2021 | Washington State | 24 | at | Oregon (10-4,7-3) | 38 | |||
| 11/19/2021 | Arizona (1-11,1-8) | 18 | at | Washington State | 44 | |||
| 11/26/2021 | Washington State | 40 | at | Washington (4-8,3-6) | 13 | |||
| 12/31/2021 | Washington State | 21 | vs | Central Michigan (9-4) | 24 | Sun Bowl - El Paso TX | vs MAC |
| vs Washington State | vs Other Opponents | Washington State compared to OOs | |
| Record: | 6-7 | 81-71 | |
| Points Scored: | 24.23 | 28.64 | 4.41 |
| Points Allowed: | 27.85 | 25.97 | 1.88 |
| Margin: | -3.62 | 2.67 | 6.29 |
| Total Points: | 52.08 | 54.61 | -2.53 |