| 9/4/2021 | San Jose State (5-7) | 7 | at | Southern California | 30 | MW | ||
| 9/11/2021 | Stanford (3-9,2-7) | 42 | at | Southern California | 28 | |||
| 9/18/2021 | Southern California | 45 | at | Washington State (7-6,6-3) | 14 | |||
| 9/25/2021 | Oregon State (7-6,5-4) | 45 | at | Southern California | 27 | |||
| 10/2/2021 | Southern California | 37 | at | Colorado (4-8,3-6) | 14 | |||
| 10/9/2021 | Utah (10-4,9-1) | 42 | at | Southern California | 26 | |||
| 10/23/2021 | Southern California | 16 | at | Notre Dame (11-2) | 31 | at ND | ||
| 10/30/2021 | Arizona (1-11,1-8) | 34 | at | Southern California | 41 | |||
| 11/6/2021 | Southern California | 16 | at | Arizona State (8-5,6-3) | 31 | |||
| 11/20/2021 | UCLA (8-4,6-3) | 62 | at | Southern California | 33 | |||
| 11/27/2021 | BYU (10-3) | 35 | at | Southern California | 31 | Ind | ||
| 12/4/2021 | Southern California | 14 | at | California (5-7,4-5) | 24 |
| vs Southern California | vs Other Opponents | Southern California compared to OOs | |
| Record: | 8-4 | 71-68 | |
| Points Scored: | 31.75 | 27.26 | -4.49 |
| Points Allowed: | 28.67 | 24.91 | 3.76 |
| Margin: | 3.08 | 2.35 | -0.73 |
| Total Points: | 60.42 | 52.17 | 8.25 |