| 9/4/2021 | Army (9-4) | 43 | at | Georgia State | 10 | Ind | ||
| 9/11/2021 | Georgia State | 17 | at | North Carolina (6-7) | 59 | at ACC | ||
| 9/18/2021 | UNC-Charlotte (5-7) | 9 | at | Georgia State | 20 | CUSA | ||
| 9/25/2021 | Georgia State | 24 | at | Auburn (6-7) | 34 | at SEC | ||
| 10/2/2021 | Appalachian State (10-4,7-2) | 45 | at | Georgia State | 16 | |||
| 10/9/2021 | Georgia State | 55 | at | UL Monroe (4-8,2-6) | 21 | |||
| 10/23/2021 | Texas State (4-8,3-5) | 16 | at | Georgia State | 28 | |||
| 10/30/2021 | Georgia State | 21 | at | Georgia Southern (3-9,2-6) | 14 | |||
| 11/4/2021 | Georgia State | 17 | at | UL Lafayette (13-1,9-0) | 21 | |||
| 11/13/2021 | Georgia State | 42 | at | Coastal Carolina (11-2,6-2) | 40 | |||
| 11/20/2021 | Arkansas State (2-10,1-7) | 20 | at | Georgia State | 28 | |||
| 11/27/2021 | Troy (5-7,3-5) | 10 | at | Georgia State | 37 | |||
| 12/25/2021 | Georgia State | 51 | vs | Ball State (6-7) | 20 | Camelia Bowl - Montgomery AL | vs MAC |
| vs Georgia State | vs Other Opponents | Georgia State compared to OOs | |
| Record: | 5-8 | 79-73 | |
| Points Scored: | 27.08 | 28.54 | 1.46 |
| Points Allowed: | 28.15 | 27.64 | 0.51 |
| Margin: | -1.07 | 0.90 | 1.97 |
| Total Points: | 55.23 | 56.18 | -0.95 |