| 9/3/2021 | St Francis PA (5-6) | 15 | at | Eastern Michigan | 35 | NE (1AA) | ||
| 9/11/2021 | Eastern Michigan | 7 | at | Wisconsin (9-4) | 34 | at B10 | ||
| 9/18/2021 | Eastern Michigan | 42 | at | Massachusetts (1-11) | 28 | at Ind | ||
| 9/25/2021 | Texas State (4-8) | 21 | at | Eastern Michigan | 59 | SBC | ||
| 10/2/2021 | Eastern Michigan | 20 | at | Northern Illinois (9-5,7-2) | 27 | |||
| 10/9/2021 | Miami-Ohio (7-6,5-3) | 12 | at | Eastern Michigan | 13 | |||
| 10/16/2021 | Ball State (6-7,4-4) | 38 | at | Eastern Michigan | 31 | |||
| 10/23/2021 | Eastern Michigan | 55 | at | Bowling Green (4-8,2-6) | 24 | |||
| 11/2/2021 | Eastern Michigan | 52 | at | Toledo (7-6,5-3) | 49 | |||
| 11/9/2021 | Ohio (3-9,3-5) | 34 | at | Eastern Michigan | 26 | |||
| 11/16/2021 | Western Michigan (8-5,4-4) | 21 | at | Eastern Michigan | 22 | |||
| 11/26/2021 | Eastern Michigan | 10 | at | Central Michigan (9-4,6-2) | 31 | |||
| 12/18/2021 | Eastern Michigan | 20 | vs | Liberty (8-5) | 56 | Lending Tree Bowl - Mobile AL | vs Ind |
| vs Eastern Michigan | vs Other Opponents | Eastern Michigan compared to OOs | |
| Record: | 6-7 | 74-77 | |
| Points Scored: | 30.00 | 26.79 | -3.21 |
| Points Allowed: | 30.15 | 27.01 | 3.14 |
| Margin: | -0.15 | -0.22 | -0.07 |
| Total Points: | 60.15 | 53.80 | 6.35 |