| 8/28/2021 | Connecticut (1-11) | 0 | at | Fresno State | 45 | Ind | ||
| 9/4/2021 | Fresno State | 24 | at | Oregon (10-4) | 31 | at P12 | ||
| 9/11/2021 | Cal Poly (2-9) | 10 | at | Fresno State | 63 | BSky (1AA) | ||
| 9/18/2021 | Fresno State | 40 | at | UCLA (8-4) | 37 | at P12 | ||
| 9/24/2021 | UNLV (2-10,2-6) | 30 | at | Fresno State | 38 | |||
| 10/2/2021 | Fresno State | 24 | at | Hawaii (6-7,3-5) | 27 | |||
| 10/16/2021 | Fresno State | 17 | at | Wyoming (7-6,2-6) | 0 | |||
| 10/23/2021 | Nevada (8-5,5-3) | 32 | at | Fresno State | 34 | |||
| 10/30/2021 | Fresno State | 30 | vs | San Diego State (12-2,7-2) | 20 | Carson CA | ||
| 11/6/2021 | Boise State (7-5,5-3) | 40 | at | Fresno State | 14 | |||
| 11/13/2021 | New Mexico (3-9,1-7) | 7 | at | Fresno State | 34 | |||
| 11/25/2021 | Fresno State | 40 | at | San Jose State (5-7,3-5) | 9 | |||
| 12/18/2021 | UTEP (7-6) | 24 | vs | Fresno State | 31 | New Mexico Bowl - Albuquerque NM | CUSA |
| vs Fresno State | vs Other Opponents | Fresno State compared to OOs | |
| Record: | 3-10 | 75-75 | |
| Points Scored: | 20.54 | 25.53 | 4.99 |
| Points Allowed: | 33.38 | 27.37 | 6.01 |
| Margin: | -12.84 | -1.84 | 11.00 |
| Total Points: | 53.92 | 52.90 | 1.02 |