| 9/18/2021 | Holy Cross (10-3) | 20 | at | Yale | 17 | Pat | ||
| 9/25/2021 | Cornell (2-8,1-6) | 17 | at | Yale | 23 | |||
| 10/2/2021 | Yale | 34 | at | Lehigh (3-8) | 0 | at Pat | ||
| 10/9/2021 | Yale | 17 | at | Dartmouth (9-1,6-1) | 24 | OT | ||
| 10/16/2021 | Yale | 15 | at | Connecticut (1-11) | 21 | at Ind | ||
| 10/23/2021 | Pennsylvania (3-7,1-6) | 28 | at | Yale | 42 | |||
| 10/30/2021 | Columbia (7-3,4-3) | 30 | at | Yale | 37 | |||
| 11/6/2021 | Yale | 63 | at | Brown (2-8,1-6) | 38 | |||
| 11/13/2021 | Yale | 20 | at | Princeton (9-1,6-1) | 35 | |||
| 11/20/2021 | Harvard (8-2,5-2) | 34 | at | Yale | 31 |
| vs Yale | vs Other Opponents | Yale compared to OOs | |
| Record: | 5-5 | 49-47 | |
| Points Scored: | 24.70 | 24.88 | 0.18 |
| Points Allowed: | 29.90 | 24.07 | 5.83 |
| Margin: | -5.20 | 0.81 | 6.01 |
| Total Points: | 54.60 | 48.95 | 5.65 |