| 9/2/2021 | Western Illinois (2-9) | 21 | at | Ball State | 31 | MVC (1AA) | ||
| 9/11/2021 | Ball State | 13 | at | Penn State (7-6) | 44 | at B10 | ||
| 9/18/2021 | Ball State | 12 | at | Wyoming (7-6) | 45 | at MW | ||
| 9/25/2021 | Toledo (7-6,5-3) | 22 | at | Ball State | 12 | |||
| 10/2/2021 | Army (9-4) | 16 | at | Ball State | 28 | Ind | ||
| 10/9/2021 | Ball State | 45 | at | Western Michigan (8-5,4-4) | 20 | |||
| 10/16/2021 | Ball State | 38 | at | Eastern Michigan (7-6,4-4) | 31 | |||
| 10/23/2021 | Miami-Ohio (7-6,5-3) | 24 | at | Ball State | 17 | |||
| 11/2/2021 | Ball State | 31 | at | Akron (2-10,1-7) | 25 | |||
| 11/10/2021 | Ball State | 29 | at | Northern Illinois (9-5,7-2) | 30 | |||
| 11/17/2021 | Central Michigan (9-4,6-2) | 37 | at | Ball State | 17 | |||
| 11/23/2021 | Buffalo (4-8,2-6) | 3 | at | Ball State | 20 | |||
| 12/25/2021 | Georgia State (8-5) | 51 | vs | Ball State | 20 | Camelia Bowl - Montgomery AL | SBC |
| vs Ball State | vs Other Opponents | Ball State compared to OOs | |
| Record: | 7-6 | 79-74 | |
| Points Scored: | 28.38 | 28.96 | 0.58 |
| Points Allowed: | 24.08 | 27.90 | -3.82 |
| Margin: | 4.30 | 1.06 | -3.24 |
| Total Points: | 52.46 | 56.86 | -4.40 |