| 9/4/2021 | Gardner-Webb (4-7) | 25 | at | Georgia Southern | 30 | BigS (1AA) | ||
| 9/11/2021 | Georgia Southern | 6 | at | Florida Atlantic (5-7) | 38 | at CUSA | ||
| 9/18/2021 | Georgia Southern | 10 | at | Arkansas (9-4) | 45 | at SEC | ||
| 9/25/2021 | UL Lafayette (13-1,9-0) | 28 | at | Georgia Southern | 20 | |||
| 10/2/2021 | Arkansas State (2-10,1-7) | 33 | at | Georgia Southern | 59 | |||
| 10/9/2021 | Georgia Southern | 24 | at | Troy (5-7,3-5) | 27 | |||
| 10/14/2021 | Georgia Southern | 14 | at | South Alabama (5-7,2-6) | 41 | |||
| 10/30/2021 | Georgia State (8-5,6-2) | 21 | at | Georgia Southern | 14 | |||
| 11/6/2021 | Coastal Carolina (11-2,6-2) | 28 | at | Georgia Southern | 8 | |||
| 11/13/2021 | Georgia Southern | 38 | at | Texas State (4-8,3-5) | 30 | |||
| 11/20/2021 | BYU (10-3) | 34 | at | Georgia Southern | 17 | Ind | ||
| 11/27/2021 | Georgia Southern | 3 | at | Appalachian State (10-4,7-2) | 27 |
| vs Georgia Southern | vs Other Opponents | Georgia Southern compared to OOs | |
| Record: | 9-3 | 77-62 | |
| Points Scored: | 31.42 | 29.17 | -2.25 |
| Points Allowed: | 20.25 | 26.71 | -6.46 |
| Margin: | 11.17 | 2.46 | -8.71 |
| Total Points: | 51.67 | 55.88 | -4.21 |