| 9/4/2021 | Campbell | 7 | at | Liberty (8-5) | 48 | at Ind | ||
| 9/11/2021 | Elon (6-5) | 24 | at | Campbell | 23 | CAAF | ||
| 9/18/2021 | Presbyterian (2-9) | 0 | at | Campbell | 72 | Pio | ||
| 10/2/2021 | Campbell | 48 | at | North Alabama (3-8,3-4) | 31 | |||
| 10/9/2021 | Campbell | 42 | at | Gardner-Webb (4-7,2-5) | 28 | |||
| 10/16/2021 | Monmouth NJ (7-4,6-1) | 34 | at | Campbell | 17 | |||
| 10/23/2021 | Kennesaw St (11-2,7-0) | 30 | at | Campbell | 7 | |||
| 10/30/2021 | Campbell | 14 | at | Charleston Southern (4-6,3-4) | 27 | |||
| 11/6/2021 | Campbell | 14 | at | James Madison (12-2) | 51 | at CAAF | ||
| 11/13/2021 | Hampton (5-6,3-4) | 28 | at | Campbell | 21 | |||
| 11/20/2021 | Campbell | 17 | at | Robert Morris (4-6,3-5) | 20 | OT |
| vs Campbell | vs Other Opponents | Campbell compared to OOs | |
| Record: | 8-3 | 58-57 | |
| Points Scored: | 29.18 | 30.37 | 1.19 |
| Points Allowed: | 25.64 | 28.87 | -3.23 |
| Margin: | 3.54 | 1.50 | -2.04 |
| Total Points: | 54.82 | 59.24 | -4.42 |