| 9/4/2021 | Southern (4-7) | 3 | at | Troy | 55 | SWAC (1AA) | ||
| 9/11/2021 | Liberty (8-5) | 21 | at | Troy | 13 | Ind | ||
| 9/18/2021 | Troy | 21 | at | Southern Miss (3-9) | 9 | at CUSA | ||
| 9/25/2021 | Troy | 16 | at | UL Monroe (4-8,2-6) | 29 | |||
| 10/2/2021 | Troy | 14 | at | South Carolina (7-6) | 23 | at SEC | ||
| 10/9/2021 | Georgia Southern (3-9,2-6) | 24 | at | Troy | 27 | |||
| 10/16/2021 | Troy | 31 | at | Texas State (4-8,3-5) | 28 | |||
| 10/28/2021 | Troy | 28 | at | Coastal Carolina (11-2,6-2) | 35 | |||
| 11/6/2021 | South Alabama (5-7,2-6) | 24 | at | Troy | 31 | |||
| 11/13/2021 | UL Lafayette (13-1,9-0) | 35 | at | Troy | 21 | |||
| 11/20/2021 | Appalachian State (10-4,7-2) | 45 | at | Troy | 7 | |||
| 11/27/2021 | Troy | 10 | at | Georgia State (8-5,6-2) | 37 |
| vs Troy | vs Other Opponents | Troy compared to OOs | |
| Record: | 7-5 | 73-66 | |
| Points Scored: | 26.08 | 27.38 | 1.30 |
| Points Allowed: | 22.83 | 26.52 | -3.69 |
| Margin: | 3.25 | 0.86 | -2.39 |
| Total Points: | 48.91 | 53.90 | -4.99 |