| 9/4/2021 | Alabama | 44 | vs | Miami-Florida (7-5) | 13 | | Atlanta GA | vs ACC |
| 9/11/2021 | Mercer (7-3) | 14 | at | Alabama | 48 | | | SoCon (1AA) |
| 9/18/2021 | Alabama | 31 | at | Florida (6-7,2-6) | 29 | | | |
| 9/25/2021 | Southern Miss (3-9) | 14 | at | Alabama | 63 | | | CUSA |
| 10/2/2021 | Mississippi (10-3,6-2) | 21 | at | Alabama | 42 | | | |
| 10/9/2021 | Alabama | 38 | at | Texas A&M (8-4,4-4) | 41 | | | |
| 10/16/2021 | Alabama | 49 | at | Mississippi State (7-6,4-4) | 9 | | | |
| 10/23/2021 | Tennessee (7-6,4-4) | 24 | at | Alabama | 52 | | | |
| 11/6/2021 | LSU (6-7,3-5) | 14 | at | Alabama | 20 | | | |
| 11/13/2021 | New Mexico State (2-10) | 3 | at | Alabama | 59 | | | Ind |
| 11/20/2021 | Arkansas (9-4,4-4) | 35 | at | Alabama | 42 | | | |
| 11/27/2021 | Alabama | 24 | at | Auburn (6-7,3-5) | 22 | 4OT | | |
| 12/4/2021 | Georgia (14-1,9-1) | 24 | vs | Alabama | 41 | | SEC Championship - Atlanta GA | |
| 12/31/2021 | Cincinnati (13-1) | 6 | vs | Alabama | 27 | | FBS Semifinal - Arlngton TX | AAC |
| 1/10/2022 | Georgia (14-1,9-1) | 33 | vs | Alabama | 18 | | FBS Championship - Indianapolis IN | |