| 9/4/2021 | UL Monroe | 10 | at | Kentucky (10-3) | 45 | at SEC | ||
| 9/18/2021 | Jackson State (11-2) | 7 | at | UL Monroe | 12 | SWAC (1AA) | ||
| 9/25/2021 | Troy (5-7,3-5) | 16 | at | UL Monroe | 29 | |||
| 10/2/2021 | UL Monroe | 6 | at | Coastal Carolina (11-2,6-2) | 59 | |||
| 10/9/2021 | Georgia State (8-5,6-2) | 55 | at | UL Monroe | 21 | |||
| 10/16/2021 | Liberty (8-5) | 28 | at | UL Monroe | 31 | Ind | ||
| 10/23/2021 | South Alabama (5-7,2-6) | 31 | at | UL Monroe | 41 | |||
| 10/30/2021 | UL Monroe | 28 | at | Appalachian State (10-4,7-2) | 59 | |||
| 11/6/2021 | UL Monroe | 19 | at | Texas State (4-8,3-5) | 27 | |||
| 11/13/2021 | Arkansas State (2-10,1-7) | 27 | at | UL Monroe | 24 | |||
| 11/20/2021 | UL Monroe | 14 | at | LSU (6-7) | 27 | at SEC | ||
| 11/27/2021 | UL Monroe | 16 | at | UL Lafayette (13-1,9-0) | 21 |
| vs UL Monroe | vs Other Opponents | UL Monroe compared to OOs | |
| Record: | 8-4 | 85-57 | |
| Points Scored: | 33.50 | 29.06 | -4.44 |
| Points Allowed: | 20.92 | 24.94 | -4.02 |
| Margin: | 12.58 | 4.12 | -8.46 |
| Total Points: | 54.42 | 54.00 | 0.42 |