| 9/2/2021 | Bowling Green | 6 | at | Tennessee | 38 | MAC | ||
| 9/4/2021 | Rice | 17 | at | Arkansas | 38 | CUSA | ||
| Akron | 10 | at | Auburn | 60 | MAC | |||
| Georgia | 10 | vs | Clemson | 3 | Charlotte NC | vs ACC | ||
| Florida Atlantic | 14 | at | Florida | 35 | CUSA | |||
| UL Monroe | 10 | at | Kentucky | 45 | SBC | |||
| Alabama | 44 | vs | Miami-Florida | 13 | Atlanta GA | vs ACC | ||
| Louisiana Tech | 34 | at | Mississippi State | 35 | CUSA | |||
| Central Michigan | 24 | at | Missouri | 34 | MAC | |||
| Eastern Illinois | 0 | at | South Carolina | 46 | OVC (1AA) | |||
| Kent State | 10 | at | Texas A&M | 41 | MAC | |||
| LSU | 27 | at | UCLA | 38 | @ P12 | |||
| East Tennessee St | 23 | at | Vanderbilt | 3 | SoCon (1AA) | |||
| 9/6/2021 | Louisville | 24 | vs | Mississippi | 43 | Atlanta GA | vs ACC | |
| 9/11/2021 | Mercer | 14 | at | Alabama | 48 | SoCon (1AA) | ||
| Texas | 21 | at | Arkansas | 40 | B12 | |||
| Alabama State | 0 | at | Auburn | 62 | SWAC (1AA) | |||
| Texas A&M | 10 | vs | Colorado | 7 | Denver CO | vs P12 | ||
| Vanderbilt | 24 | at | Colorado State | 21 | @ MW | |||
| South Carolina | 20 | at | East Carolina | 17 | @ AAC | |||
| UAB | 7 | at | Georgia | 56 | CUSA | |||
| Missouri | 28 | at | Kentucky | 35 | ||||
| McNeese State | 7 | at | LSU | 34 | SLC (1AA) | |||
| Austin Peay | 17 | at | Mississippi | 54 | OVC (1AA) | |||
| North Carolina State | 10 | at | Mississippi State | 24 | ACC | |||
| Florida | 42 | at | South Florida | 20 | @ AAC | |||
| Pittsburgh | 41 | at | Tennessee | 34 | ACC | |||
| 9/18/2021 | Georgia Southern | 10 | at | Arkansas | 45 | SBC | ||
| Alabama | 31 | at | Florida | 29 | ||||
| South Carolina | 13 | at | Georgia | 40 | ||||
| Chattanooga | 23 | at | Kentucky | 28 | SoCon (1AA) | |||
| Central Michigan | 21 | at | LSU | 49 | MAC | |||
| Mississippi State | 29 | at | Memphis | 31 | @ AAC | |||
| Tulane | 21 | at | Mississippi | 61 | AAC | |||
| SE Missouri State | 28 | at | Missouri | 59 | OVC (1AA) | |||
| Auburn | 20 | at | Penn State | 28 | @ B10 | |||
| Tennessee Tech | 0 | at | Tennessee | 56 | OVC (1AA) | |||
| New Mexico | 0 | at | Texas A&M | 34 | MW | |||
| Stanford | 41 | at | Vanderbilt | 23 | P12 | |||
| 9/25/2021 | Southern Miss | 14 | at | Alabama | 63 | CUSA | ||
| Texas A&M | 10 | vs | Arkansas | 20 | Arlington TX | |||
| Georgia State | 24 | at | Auburn | 34 | SBC | |||
| Missouri | 34 | at | Boston College | 41 | OT | @ ACC | ||
| Tennessee | 14 | at | Florida | 38 | ||||
| LSU | 28 | at | Mississippi State | 25 | ||||
| Kentucky | 16 | at | South Carolina | 10 | ||||
| Georgia | 62 | at | Vanderbilt | 0 | ||||
| 10/2/2021 | Mississippi | 21 | at | Alabama | 42 | |||
| Arkansas | 0 | at | Georgia | 37 | ||||
| Florida | 13 | at | Kentucky | 20 | ||||
| Auburn | 24 | at | LSU | 19 | ||||
| Tennessee | 62 | at | Missouri | 24 | ||||
| Troy | 14 | at | South Carolina | 23 | SBC | |||
| Mississippi State | 26 | at | Texas A&M | 22 | ||||
| Connecticut | 28 | at | Vanderbilt | 30 | Ind | |||
| 10/9/2021 | Georgia | 34 | at | Auburn | 10 | |||
| Vanderbilt | 0 | at | Florida | 42 | ||||
| LSU | 21 | at | Kentucky | 42 | ||||
| Arkansas | 51 | at | Mississippi | 52 | ||||
| North Texas | 35 | at | Missouri | 48 | CUSA | |||
| South Carolina | 20 | at | Tennessee | 45 | ||||
| Alabama | 38 | at | Texas A&M | 41 | ||||
| 10/16/2021 | Auburn | 38 | at | Arkansas | 23 | |||
| Kentucky | 13 | at | Georgia | 30 | ||||
| Florida | 42 | at | LSU | 49 | ||||
| Alabama | 49 | at | Mississippi State | 9 | ||||
| Texas A&M | 35 | at | Missouri | 14 | ||||
| Vanderbilt | 20 | at | South Carolina | 21 | ||||
| Mississippi | 31 | at | Tennessee | 26 | ||||
| 10/23/2021 | Tennessee | 24 | at | Alabama | 52 | |||
| Ark Pine Bluff | 3 | vs | Arkansas | 45 | Little Rock AR | vs SWAC (1AA) | ||
| LSU | 17 | at | Mississippi | 31 | ||||
| South Carolina | 14 | at | Texas A&M | 44 | ||||
| Mississippi State | 45 | at | Vanderbilt | 6 | ||||
| 10/30/2021 | Mississippi | 20 | at | Auburn | 31 | |||
| Georgia | 34 | vs | Florida | 7 | Jacksonville FL | |||
| Kentucky | 17 | at | Mississippi State | 31 | ||||
| Missouri | 37 | at | Vanderbilt | 28 | ||||
| 11/6/2021 | LSU | 14 | at | Alabama | 20 | |||
| Mississippi State | 28 | at | Arkansas | 31 | ||||
| Missouri | 6 | at | Georgia | 43 | ||||
| Tennessee | 45 | at | Kentucky | 42 | ||||
| Liberty | 14 | at | Mississippi | 27 | Ind | |||
| Florida | 17 | at | South Carolina | 40 | ||||
| Auburn | 3 | at | Texas A&M | 20 | ||||
| 11/13/2021 | New Mexico State | 3 | at | Alabama | 59 | Ind | ||
| Mississippi State | 43 | at | Auburn | 34 | ||||
| Samford | 52 | at | Florida | 70 | SoCon (1AA) | |||
| Arkansas | 16 | at | LSU | 13 | OT | |||
| Texas A&M | 19 | at | Mississippi | 29 | ||||
| South Carolina | 28 | at | Missouri | 31 | ||||
| Georgia | 41 | at | Tennessee | 17 | ||||
| Kentucky | 34 | at | Vanderbilt | 17 | ||||
| 11/20/2021 | Arkansas | 35 | at | Alabama | 42 | |||
| Charleston Southern | 7 | at | Georgia | 56 | BigS (1AA) | |||
| New Mexico State | 16 | at | Kentucky | 56 | Ind | |||
| UL Monroe | 14 | at | LSU | 27 | SBC | |||
| Vanderbilt | 17 | at | Mississippi | 31 | ||||
| Tennessee State | 10 | at | Mississippi State | 55 | OVC (1AA) | |||
| Florida | 23 | at | Missouri | 24 | OT | |||
| Auburn | 17 | at | South Carolina | 21 | ||||
| South Alabama | 14 | at | Tennessee | 60 | SBC | |||
| Prairie View | 3 | at | Texas A&M | 52 | SWAC (1AA) | |||
| 11/25/2021 | Mississippi | 31 | at | Mississippi State | 21 | |||
| 11/26/2021 | Missouri | 17 | at | Arkansas | 34 | |||
| 11/27/2021 | Alabama | 24 | at | Auburn | 22 | 4OT | ||
| Florida State | 21 | at | Florida | 24 | ACC | |||
| Georgia | 45 | at | Georgia Tech | 0 | @ ACC | |||
| Kentucky | 52 | at | Louisville | 21 | @ ACC | |||
| Texas A&M | 24 | at | LSU | 27 | ||||
| Clemson | 30 | at | South Carolina | 0 | ACC | |||
| Vanderbilt | 21 | at | Tennessee | 45 | ||||
| 12/4/2021 | Georgia | 24 | vs | Alabama | 41 | SEC Championship - Atlanta GA | ||
| 12/22/2021 | Missouri | 22 | vs | Army | 24 | Armed Forces Bowl - Fort Worth TX | vs Ind | |
| 12/23/2021 | UCF | 29 | vs | Florida | 17 | Gasparilla Bowl - Saint Petersburg FL | vs AAC | |
| 12/28/2021 | Houston | 17 | vs | Auburn | 13 | Birmingham Bowl - Birmingham AL | vs AAC | |
| Mississippi State | 7 | vs | Texas Tech | 34 | Liberty Bowl - Memphis TN | vs B12 | ||
| 12/30/2021 | Tennessee | 45 | vs | Purdue | 48 | OT | Music City Bowl - Nashville TN | vs B10 |
| North Carolina | 21 | vs | South Carolina | 38 | Dukes Mayo Bowl - Charlotte NC | vs ACC | ||
| 12/31/2021 | Cincinnati | 6 | vs | Alabama | 27 | FBS Semifinal - Arlngton TX | vs AAC | |
| Georgia | 34 | vs | Michigan | 11 | FBS Semifinal - Miami Gardens FL | vs B10 | ||
| 1/1/2022 | Penn State | 10 | vs | Arkansas | 24 | Outback Bowl - Tampa FL | vs B10 | |
| Iowa | 17 | vs | Kentucky | 20 | Citrus Bowl - Orlando FL | vs B10 | ||
| Baylor | 21 | vs | Mississippi | 7 | Sugar Bowl - New Orleans LA | vs B12 | ||
| 1/4/2022 | LSU | 20 | vs | Kansas State | 42 | Texas Bowl - Houston TX | vs B12 | |
| 1/10/2022 | Georgia | 33 | vs | Alabama | 18 | FBS Championship - Indianapolis IN |