| 9/2/2021 | Tennessee Tech (3-8) | 14 | at | Samford | 52 | OVC | ||
| 9/11/2021 | Samford | 27 | at | Tennessee-Martin (10-3) | 33 | at OVC | ||
| 9/18/2021 | Samford | 42 | at | Western Carolina (4-7,4-4) | 37 | |||
| 9/25/2021 | East Tennessee St (11-2,7-1) | 55 | at | Samford | 48 | OT | ||
| 10/2/2021 | Samford | 42 | at | Mercer (7-3,6-2) | 45 | |||
| 10/16/2021 | Samford | 27 | at | Wofford (1-10,0-8) | 24 | |||
| 10/23/2021 | Chattanooga (6-5,5-3) | 55 | at | Samford | 13 | |||
| 10/30/2021 | Samford | 45 | at | VMI (6-5,4-4) | 46 | |||
| 11/6/2021 | The Citadel (4-7,3-5) | 14 | at | Samford | 35 | |||
| 11/13/2021 | Samford | 52 | at | Florida (6-7) | 70 | at SEC | ||
| 11/20/2021 | Furman (6-5,4-4) | 41 | at | Samford | 34 |
| vs Samford | vs Other Opponents | Samford compared to OOs | |
| Record: | 7-4 | 57-58 | |
| Points Scored: | 39.45 | 26.57 | -12.88 |
| Points Allowed: | 37.91 | 27.41 | 10.50 |
| Margin: | 1.54 | -0.84 | -2.38 |
| Total Points: | 77.36 | 53.98 | 23.38 |