| 9/3/2021 | Northern Colorado (3-8) | 7 | at | Colorado | 35 | BSky (1AA) | ||
| 9/11/2021 | Texas A&M (8-4) | 10 | vs | Colorado | 7 | Denver CO | SEC | |
| 9/18/2021 | Minnesota (9-4) | 30 | at | Colorado | 0 | B10 | ||
| 9/25/2021 | Colorado | 13 | at | Arizona State (8-5,6-3) | 35 | |||
| 10/2/2021 | Southern California (4-8,3-6) | 37 | at | Colorado | 14 | |||
| 10/16/2021 | Arizona (1-11,1-8) | 0 | at | Colorado | 34 | |||
| 10/23/2021 | Colorado | 3 | at | California (5-7,4-5) | 26 | |||
| 10/30/2021 | Colorado | 29 | at | Oregon (10-4,7-3) | 52 | |||
| 11/6/2021 | Oregon State (7-6,5-4) | 34 | at | Colorado | 37 | 2OT | ||
| 11/13/2021 | Colorado | 20 | at | UCLA (8-4,6-3) | 44 | |||
| 11/20/2021 | Washington (4-8,3-6) | 17 | at | Colorado | 20 | |||
| 11/26/2021 | Colorado | 13 | at | Utah (10-4,9-1) | 28 |
| vs Colorado | vs Other Opponents | Colorado compared to OOs | |
| Record: | 8-4 | 69-69 | |
| Points Scored: | 26.67 | 27.38 | 0.71 |
| Points Allowed: | 18.75 | 24.91 | -6.16 |
| Margin: | 7.92 | 2.47 | -5.45 |
| Total Points: | 45.42 | 52.29 | -6.87 |