| 9/2/2021 | Austin Peay (6-5) | 30 | at | Chattanooga | 20 | OVC | ||
| 9/11/2021 | Chattanooga | 20 | at | North Alabama (3-8) | 0 | at BigS | ||
| 9/18/2021 | Chattanooga | 23 | at | Kentucky (10-3) | 28 | at SEC | ||
| 10/2/2021 | Western Carolina (4-7,4-4) | 17 | at | Chattanooga | 45 | |||
| 10/9/2021 | Chattanooga | 34 | at | VMI (6-5,4-4) | 37 | OT | ||
| 10/16/2021 | East Tennessee St (11-2,7-1) | 16 | at | Chattanooga | 21 | |||
| 10/23/2021 | Chattanooga | 55 | at | Samford (4-7,3-5) | 13 | |||
| 10/30/2021 | Furman (6-5,4-4) | 3 | at | Chattanooga | 13 | |||
| 11/6/2021 | Chattanooga | 35 | at | Wofford (1-10,0-8) | 10 | |||
| 11/13/2021 | Chattanooga | 6 | at | Mercer (7-3,6-2) | 10 | |||
| 11/20/2021 | The Citadel (4-7,3-5) | 24 | at | Chattanooga | 21 |
| vs Chattanooga | vs Other Opponents | Chattanooga compared to OOs | |
| Record: | 5-6 | 57-56 | |
| Points Scored: | 17.09 | 31.17 | 14.08 |
| Points Allowed: | 26.64 | 30.27 | -3.63 |
| Margin: | -9.55 | 0.90 | 10.45 |
| Total Points: | 43.73 | 61.44 | -17.71 |