| 9/4/2021 | Tulane | 35 | at | Oklahoma (11-2) | 40 | at B12 | ||
| 9/11/2021 | Morgan State (2-9) | 20 | at | Tulane | 69 | MEAC (1AA) | ||
| 9/18/2021 | Tulane | 21 | at | Mississippi (10-3) | 61 | at SEC | ||
| 9/25/2021 | UAB (9-4) | 28 | at | Tulane | 21 | CUSA | ||
| 10/2/2021 | Tulane | 29 | at | East Carolina (7-5,5-3) | 52 | |||
| 10/7/2021 | Houston (12-2,8-1) | 40 | at | Tulane | 22 | |||
| 10/21/2021 | Tulane | 26 | at | SMU (8-4,4-4) | 55 | |||
| 10/30/2021 | Cincinnati (13-1,9-0) | 31 | at | Tulane | 12 | |||
| 11/6/2021 | Tulane | 10 | at | UCF (9-4,5-3) | 14 | |||
| 11/13/2021 | Tulsa (7-6,5-3) | 20 | at | Tulane | 13 | OT | ||
| 11/20/2021 | South Florida (2-10,1-7) | 14 | at | Tulane | 45 | |||
| 11/27/2021 | Tulane | 28 | at | Memphis (6-6,3-5) | 33 |
| vs Tulane | vs Other Opponents | Tulane compared to OOs | |
| Record: | 10-2 | 86-54 | |
| Points Scored: | 34.00 | 30.77 | -3.23 |
| Points Allowed: | 27.58 | 25.60 | 1.98 |
| Margin: | 6.42 | 5.17 | -1.25 |
| Total Points: | 61.58 | 56.37 | 5.21 |