| 9/4/2021 | Kent State | 10 | at | Texas A&M (8-4) | 41 | at SEC | ||
| 9/11/2021 | VMI (6-5) | 10 | at | Kent State | 60 | SoCon (1AA) | ||
| 9/18/2021 | Kent State | 7 | at | Iowa (10-4) | 30 | at B10 | ||
| 9/25/2021 | Kent State | 16 | at | Maryland (7-6) | 37 | at B10 | ||
| 10/2/2021 | Bowling Green (4-8,2-6) | 20 | at | Kent State | 27 | |||
| 10/9/2021 | Buffalo (4-8,2-6) | 38 | at | Kent State | 48 | |||
| 10/16/2021 | Kent State | 31 | at | Western Michigan (8-5,4-4) | 64 | |||
| 10/23/2021 | Kent State | 34 | at | Ohio (3-9,3-5) | 27 | |||
| 11/3/2021 | Northern Illinois (9-5,7-2) | 47 | at | Kent State | 52 | |||
| 11/10/2021 | Kent State | 30 | at | Central Michigan (9-4,6-2) | 54 | |||
| 11/20/2021 | Kent State | 38 | at | Akron (2-10,1-7) | 0 | |||
| 11/27/2021 | Miami-Ohio (7-6,5-3) | 47 | at | Kent State | 48 | OT | ||
| 12/4/2021 | Kent State | 23 | vs | Northern Illinois (9-5,7-2) | 41 | MAC Championship Detroit MI | ||
| 12/21/2021 | Kent State | 38 | vs | Wyoming (7-6) | 52 | Famous Idaho Potato Bowl - Boise ID | vs MW |
| vs Kent State | vs Other Opponents | Kent State compared to OOs | |
| Record: | 7-7 | 85-77 | |
| Points Scored: | 36.29 | 27.56 | -8.73 |
| Points Allowed: | 33.00 | 28.28 | 4.72 |
| Margin: | 3.29 | -0.72 | -4.01 |
| Total Points: | 69.29 | 55.84 | 13.45 |