| 8/28/2021 | Connecticut | 0 | at | Fresno State (10-3) | 45 | at MW | ||
| 9/4/2021 | Holy Cross (10-3) | 38 | at | Connecticut | 28 | Pat (1AA) | ||
| 9/11/2021 | Purdue (9-4) | 49 | at | Connecticut | 0 | B10 | ||
| 9/18/2021 | Connecticut | 21 | at | Army (9-4,3-0) | 52 | |||
| 9/25/2021 | Wyoming (7-6) | 24 | at | Connecticut | 22 | MW | ||
| 10/2/2021 | Connecticut | 28 | at | Vanderbilt (2-10) | 30 | at SEC | ||
| 10/9/2021 | Connecticut | 13 | at | Massachusetts (1-11,1-3) | 27 | |||
| 10/16/2021 | Yale (5-5) | 15 | at | Connecticut | 21 | Ivy (1AA) | ||
| 10/22/2021 | Middle Tenn State (7-6) | 44 | at | Connecticut | 13 | CUSA | ||
| 11/13/2021 | Connecticut | 7 | at | Clemson (10-3) | 44 | at ACC | ||
| 11/20/2021 | Connecticut | 17 | at | UCF (9-4) | 49 | at AAC | ||
| 11/27/2021 | Houston (12-2) | 45 | at | Connecticut | 17 | AAC |
| vs Connecticut | vs Other Opponents | Connecticut compared to OOs | |
| Record: | 11-1 | 80-60 | |
| Points Scored: | 38.50 | 27.55 | -10.95 |
| Points Allowed: | 15.58 | 25.25 | -9.67 |
| Margin: | 22.92 | 2.30 | -20.62 |
| Total Points: | 54.08 | 52.80 | 1.28 |