| 9/3/2021 | South Dakota State (11-4) | 42 | at | Colorado State | 23 | MVC (1AA) | ||
| 9/11/2021 | Vanderbilt (2-10) | 24 | at | Colorado State | 21 | SEC | ||
| 9/18/2021 | Colorado State | 22 | at | Toledo (7-6) | 6 | at MAC | ||
| 9/25/2021 | Colorado State | 14 | at | Iowa (10-4) | 24 | at B10 | ||
| 10/9/2021 | San Jose State (5-7,3-5) | 14 | at | Colorado State | 32 | |||
| 10/16/2021 | Colorado State | 36 | at | New Mexico (3-9,1-7) | 7 | |||
| 10/22/2021 | Colorado State | 24 | at | Utah State (11-3,7-2) | 26 | |||
| 10/30/2021 | Boise State (7-5,5-3) | 28 | at | Colorado State | 19 | |||
| 11/6/2021 | Colorado State | 17 | at | Wyoming (7-6,2-6) | 31 | |||
| 11/13/2021 | Air Force (10-3,6-2) | 35 | at | Colorado State | 21 | |||
| 11/20/2021 | Colorado State | 45 | at | Hawaii (6-7,3-5) | 50 | |||
| 11/27/2021 | Nevada (8-5,5-3) | 52 | at | Colorado State | 10 |
| vs Colorado State | vs Other Opponents | Colorado State compared to OOs | |
| Record: | 9-3 | 78-66 | |
| Points Scored: | 28.25 | 27.20 | -1.05 |
| Points Allowed: | 23.67 | 24.59 | -0.92 |
| Margin: | 4.58 | 2.61 | -1.97 |
| Total Points: | 51.92 | 51.79 | 0.13 |