| 9/2/2021 | South Florida (2-10) | 0 | at | North Carolina State | 45 | AAC | ||
| 9/11/2021 | North Carolina State | 10 | at | Mississippi State (7-6) | 24 | at SEC | ||
| 9/18/2021 | Furman (6-5) | 7 | at | North Carolina State | 45 | SoCon (1AA) | ||
| 9/25/2021 | Clemson (10-3,6-2) | 21 | at | North Carolina State | 27 | 2OT | ||
| 10/2/2021 | Louisiana Tech (3-9) | 27 | at | North Carolina State | 34 | CUSA | ||
| 10/16/2021 | North Carolina State | 33 | at | Boston College (6-6,2-6) | 7 | |||
| 10/23/2021 | North Carolina State | 30 | at | Miami-Florida (7-5,5-3) | 31 | |||
| 10/30/2021 | Louisville (6-7,4-4) | 13 | at | North Carolina State | 28 | |||
| 11/6/2021 | North Carolina State | 28 | at | Florida State (5-7,4-4) | 14 | |||
| 11/13/2021 | North Carolina State | 42 | at | Wake Forest (11-3,7-3) | 45 | |||
| 11/20/2021 | Syracuse (5-7,2-6) | 17 | at | North Carolina State | 41 | |||
| 11/26/2021 | North Carolina (6-7,4-5) | 30 | at | North Carolina State | 34 | |||
| 12/28/2021 | UCLA (8-4) | vs | North Carolina State | Cancelled Holiday Bowl - San Diego CA | P12 |
| vs North Carolina State | vs Other Opponents | North Carolina State compared to OOs | |
| Record: | 3-9 | 79-70 | |
| Points Scored: | 19.67 | 30.74 | 11.07 |
| Points Allowed: | 33.08 | 26.54 | 6.54 |
| Margin: | -13.41 | 4.20 | 17.61 |
| Total Points: | 52.75 | 57.28 | -4.53 |