| 9/2/2021 | Point (2-9) | 0 | at | Mercer | 69 | MSC (NAIA) | ||
| 9/11/2021 | Mercer | 14 | at | Alabama (13-2) | 48 | at SEC | ||
| 9/25/2021 | Mercer | 24 | at | Furman (6-5,4-4) | 3 | |||
| 10/2/2021 | Samford (4-7,3-5) | 42 | at | Mercer | 45 | |||
| 10/9/2021 | Mercer | 34 | at | Western Carolina (4-7,4-4) | 24 | |||
| 10/16/2021 | VMI (6-5,4-4) | 45 | at | Mercer | 7 | |||
| 10/23/2021 | Wofford (1-10,0-8) | 14 | at | Mercer | 45 | |||
| 10/30/2021 | Mercer | 34 | at | The Citadel (4-7,3-5) | 7 | |||
| 11/13/2021 | Chattanooga (6-5,5-3) | 6 | at | Mercer | 10 | |||
| 11/20/2021 | Mercer | 35 | at | East Tennessee St (11-2,7-1) | 38 |
| vs Mercer | vs Other Opponents | Mercer compared to OOs | |
| Record: | 3-7 | 54-52 | |
| Points Scored: | 22.70 | 29.49 | 6.79 |
| Points Allowed: | 31.70 | 29.91 | 1.79 |
| Margin: | -9.00 | -0.42 | 8.58 |
| Total Points: | 54.40 | 59.40 | -5.00 |