| 9/4/2021 | Prairie View | 40 | at | Texas Southern (3-8,2-6) | 17 | |||
| 9/11/2021 | Prairie View | 9 | at | Incarnate Word (10-3) | 40 | at SLC | ||
| 9/18/2021 | Houston Baptist (0-11) | 27 | at | Prairie View | 37 | SLC | ||
| 9/25/2021 | Grambling (4-7,3-5) | 10 | vs | Prairie View | 24 | Dallas TX | ||
| 9/30/2021 | Ark Pine Bluff (2-9,1-7) | 17 | at | Prairie View | 27 | |||
| 10/16/2021 | Prairie View | 35 | at | Bethune-Cookman (2-9,2-6) | 29 | |||
| 10/23/2021 | Prairie View | 48 | at | Southern (4-7,3-5) | 21 | |||
| 11/6/2021 | Alabama State (5-6,3-5) | 20 | at | Prairie View | 24 | |||
| 11/13/2021 | Prairie View | 29 | at | Alcorn State (6-5,5-3) | 31 | |||
| 11/20/2021 | Prairie View | 3 | at | Texas A&M (8-4) | 52 | at SEC | ||
| 11/27/2021 | Mississippi Valley State (4-7,3-5) | 24 | at | Prairie View | 19 | |||
| 12/4/2021 | Prairie View | 10 | at | Jackson State (11-2,9-0) | 27 | SWAC Championship |
| vs Prairie View | vs Other Opponents | Prairie View compared to OOs | |
| Record: | 5-7 | 54-71 | |
| Points Scored: | 26.25 | 25.34 | -0.91 |
| Points Allowed: | 25.42 | 29.38 | -3.96 |
| Margin: | 0.83 | -4.04 | -4.87 |
| Total Points: | 51.67 | 54.72 | -3.05 |