| 9/4/2021 | Akron | 10 | at | Auburn (6-7) | 60 | at SEC | ||
| 9/11/2021 | Temple (3-9) | 45 | at | Akron | 24 | AAC | ||
| 9/18/2021 | Bryant (7-4) | 14 | at | Akron | 35 | NE (1AA) | ||
| 9/25/2021 | Akron | 7 | at | Ohio State (11-2) | 59 | at B10 | ||
| 10/2/2021 | Ohio (3-9,3-5) | 34 | at | Akron | 17 | |||
| 10/9/2021 | Akron | 35 | at | Bowling Green (4-8,2-6) | 20 | |||
| 10/16/2021 | Akron | 21 | at | Miami-Ohio (7-6,5-3) | 34 | |||
| 10/23/2021 | Buffalo (4-8,2-6) | 45 | at | Akron | 10 | |||
| 11/2/2021 | Ball State (6-7,4-4) | 31 | at | Akron | 25 | |||
| 11/9/2021 | Akron | 40 | at | Western Michigan (8-5,4-4) | 45 | |||
| 11/20/2021 | Kent State (7-7,6-3) | 38 | at | Akron | 0 | |||
| 11/27/2021 | Akron | 14 | at | Toledo (7-6,5-3) | 49 |
| vs Akron | vs Other Opponents | Akron compared to OOs | |
| Record: | 10-2 | 63-76 | |
| Points Scored: | 39.50 | 28.06 | -11.44 |
| Points Allowed: | 19.83 | 28.47 | -8.64 |
| Margin: | 19.67 | -0.41 | -20.08 |
| Total Points: | 59.33 | 56.53 | 2.80 |