| 9/4/2021 | Central Michigan | 24 | at | Missouri (6-7) | 34 | at SEC | ||
| 9/11/2021 | Robert Morris (4-6) | 0 | at | Central Michigan | 45 | BigS (1AA) | ||
| 9/18/2021 | Central Michigan | 21 | at | LSU (6-7) | 49 | at SEC | ||
| 9/25/2021 | Florida Intl (1-11) | 27 | at | Central Michigan | 31 | CUSA | ||
| 10/2/2021 | Central Michigan | 17 | at | Miami-Ohio (7-6,5-3) | 28 | |||
| 10/9/2021 | Central Michigan | 30 | at | Ohio (3-9,3-5) | 27 | |||
| 10/16/2021 | Toledo (7-6,5-3) | 23 | at | Central Michigan | 26 | OT | ||
| 10/23/2021 | Northern Illinois (9-5,7-2) | 39 | at | Central Michigan | 38 | |||
| 11/3/2021 | Central Michigan | 42 | at | Western Michigan (8-5,4-4) | 30 | |||
| 11/10/2021 | Kent State (7-7,6-3) | 30 | at | Central Michigan | 54 | |||
| 11/17/2021 | Central Michigan | 37 | at | Ball State (6-7,4-4) | 17 | |||
| 11/26/2021 | Eastern Michigan (7-6,4-4) | 10 | at | Central Michigan | 31 | |||
| 12/31/2021 | Washington State (7-6) | 21 | vs | Central Michigan | 24 | Sun Bowl - El Paso TX | P12 |
| vs Central Michigan | vs Other Opponents | Central Michigan compared to OOs | |
| Record: | 4-9 | 74-79 | |
| Points Scored: | 25.77 | 28.21 | 2.44 |
| Points Allowed: | 32.31 | 29.72 | 2.59 |
| Margin: | -6.54 | -1.51 | 5.03 |
| Total Points: | 58.08 | 57.93 | 0.15 |