| 9/4/2021 | Nicholls State (6-5) | 17 | at | Memphis | 42 | SLC (1AA) | ||
| 9/11/2021 | Memphis | 55 | at | Arkansas State (2-10) | 50 | at SBC | ||
| 9/18/2021 | Mississippi State (7-6) | 29 | at | Memphis | 31 | SEC | ||
| 9/25/2021 | Texas-San Antonio (12-2) | 31 | at | Memphis | 28 | CUSA | ||
| 10/2/2021 | Memphis | 31 | at | Temple (3-9,1-7) | 34 | |||
| 10/9/2021 | Memphis | 29 | at | Tulsa (7-6,5-3) | 35 | |||
| 10/14/2021 | Navy (4-8,3-5) | 17 | at | Memphis | 35 | |||
| 10/22/2021 | Memphis | 7 | at | UCF (9-4,5-3) | 24 | |||
| 11/6/2021 | SMU (8-4,4-4) | 25 | at | Memphis | 28 | |||
| 11/13/2021 | East Carolina (7-5,5-3) | 30 | at | Memphis | 29 | OT | ||
| 11/19/2021 | Memphis | 13 | at | Houston (12-2,8-1) | 31 | |||
| 11/27/2021 | Tulane (2-10,1-7) | 28 | at | Memphis | 33 | |||
| 12/24/2021 | Memphis | vs | Hawaii (6-7) | Cancelled Hawaii Bowl - Honoluli HI | vs MW |
| vs Memphis | vs Other Opponents | Memphis compared to OOs | |
| Record: | 6-6 | 79-72 | |
| Points Scored: | 29.25 | 29.35 | 0.10 |
| Points Allowed: | 30.08 | 28.54 | 1.54 |
| Margin: | -0.83 | 0.81 | 1.64 |
| Total Points: | 59.33 | 57.89 | 1.44 |