| 9/5/2021 | Tennessee State | 10 | vs | Grambling (4-7) | 16 | Canton OH | vs SWAC | |
| 9/11/2021 | Tennessee State | 16 | vs | Jackson State (11-2) | 38 | Memphis TN | vs SWAC | |
| 9/18/2021 | Kentucky State (7-4) | 7 | at | Tennessee State | 41 | SIAC (D2) | ||
| 9/25/2021 | Tennessee State | 14 | at | SE Missouri State (4-7,4-4) | 47 | |||
| 10/2/2021 | Tennessee State | 24 | at | Austin Peay (6-5,4-3) | 22 | |||
| 10/16/2021 | Tennessee Tech (3-8,1-5) | 13 | at | Tennessee State | 20 | |||
| 10/23/2021 | Tennessee State | 28 | at | Eastern Illinois (1-10,1-6) | 0 | |||
| 10/30/2021 | Murray State (6-5,5-3) | 21 | at | Tennessee State | 27 | |||
| 11/6/2021 | Tennessee State | 20 | at | Tennessee-Martin (10-3,6-1) | 41 | |||
| 11/13/2021 | Austin Peay (6-5,4-3) | 36 | at | Tennessee State | 7 | |||
| 11/20/2021 | Tennessee State | 10 | at | Mississippi State (7-6) | 55 | at SEC |
| vs Tennessee State | vs Other Opponents | Tennessee State compared to OOs | |
| Record: | 6-5 | 58-56 | |
| Points Scored: | 26.91 | 26.54 | -0.37 |
| Points Allowed: | 19.73 | 26.52 | -6.79 |
| Margin: | 7.18 | 0.02 | -7.16 |
| Total Points: | 46.64 | 53.06 | -6.42 |