| 9/2/2021 | Austin Peay | 30 | at | Chattanooga (6-5) | 20 | at SoCon | ||
| 9/11/2021 | Austin Peay | 17 | at | Mississippi (10-3) | 54 | at SEC | ||
| 9/18/2021 | Morehead State (7-4) | 35 | at | Austin Peay | 59 | Pio | ||
| 9/25/2021 | Austin Peay | 27 | at | Eastern Kentucky (7-4) | 35 | at WAC | ||
| 10/2/2021 | Tennessee State (5-6,4-3) | 24 | at | Austin Peay | 22 | |||
| 10/9/2021 | SE Missouri State (4-7,4-4) | 30 | at | Austin Peay | 14 | |||
| 10/23/2021 | Austin Peay | 47 | at | Murray State (6-5,5-3) | 6 | |||
| 10/30/2021 | Austin Peay | 16 | at | Tennessee-Martin (10-3,6-1) | 17 | |||
| 11/6/2021 | Eastern Illinois (1-10,1-6) | 26 | at | Austin Peay | 42 | |||
| 11/13/2021 | Austin Peay | 36 | at | Tennessee State (5-6,4-3) | 7 | |||
| 11/20/2021 | Tennessee Tech (3-8,1-5) | 20 | at | Austin Peay | 48 |
| vs Austin Peay | vs Other Opponents | Austin Peay compared to OOs | |
| Record: | 5-6 | 58-54 | |
| Points Scored: | 24.91 | 25.37 | 0.46 |
| Points Allowed: | 32.55 | 26.54 | 6.01 |
| Margin: | -7.64 | -1.17 | 6.47 |
| Total Points: | 57.46 | 51.91 | 5.55 |