| 9/4/2021 | Stanford | 7 | vs | Kansas State (8-5) | 24 | Arlington TX | vs B12 | |
| 9/11/2021 | Stanford | 42 | at | Southern California (4-8,3-6) | 28 | |||
| 9/18/2021 | Stanford | 41 | at | Vanderbilt (2-10) | 23 | at SEC | ||
| 9/25/2021 | UCLA (8-4,6-3) | 35 | at | Stanford | 24 | |||
| 10/2/2021 | Oregon (10-4,7-3) | 24 | at | Stanford | 31 | OT | ||
| 10/8/2021 | Stanford | 10 | at | Arizona State (8-5,6-3) | 28 | |||
| 10/16/2021 | Stanford | 31 | at | Washington State (7-6,6-3) | 34 | |||
| 10/30/2021 | Washington (4-8,3-6) | 20 | at | Stanford | 13 | |||
| 11/5/2021 | Utah (10-4,9-1) | 52 | at | Stanford | 7 | |||
| 11/13/2021 | Stanford | 14 | at | Oregon State (7-6,5-4) | 35 | |||
| 11/20/2021 | California (5-7,4-5) | 41 | at | Stanford | 11 | |||
| 11/27/2021 | Notre Dame (11-2) | 45 | at | Stanford | 14 | ND |
| vs Stanford | vs Other Opponents | Stanford compared to OOs | |
| Record: | 9-3 | 75-66 | |
| Points Scored: | 32.42 | 28.54 | -3.88 |
| Points Allowed: | 20.42 | 25.32 | -4.90 |
| Margin: | 12.00 | 3.22 | -8.78 |
| Total Points: | 52.84 | 53.86 | -1.02 |