| 9/4/2021 | Stanford (3-9) | 7 | vs | Kansas State | 24 | Arlington TX | P12 | |
| 9/11/2021 | Southern Illinois (8-5) | 23 | at | Kansas State | 31 | MVC (1AA) | ||
| 9/18/2021 | Nevada (8-5) | 17 | at | Kansas State | 38 | MW | ||
| 9/25/2021 | Kansas State | 20 | at | Oklahoma State (12-2,8-2) | 31 | |||
| 10/2/2021 | Oklahoma (11-2,7-2) | 37 | at | Kansas State | 31 | |||
| 10/16/2021 | Iowa State (7-6,5-4) | 33 | at | Kansas State | 20 | |||
| 10/23/2021 | Kansas State | 25 | at | Texas Tech (7-6,3-6) | 24 | |||
| 10/30/2021 | TCU (5-7,3-6) | 12 | at | Kansas State | 31 | |||
| 11/6/2021 | Kansas State | 35 | at | Kansas (2-10,1-8) | 10 | |||
| 11/13/2021 | West Virginia (6-7,4-5) | 17 | at | Kansas State | 34 | |||
| 11/20/2021 | Baylor (12-2,8-2) | 20 | at | Kansas State | 10 | |||
| 11/26/2021 | Kansas State | 17 | at | Texas (5-7,3-6) | 22 | |||
| 1/4/2022 | LSU (6-7) | 20 | vs | Kansas State | 42 | Texas Bowl - Houston TX | SEC |
| vs Kansas State | vs Other Opponents | Kansas State compared to OOs | |
| Record: | 5-8 | 87-67 | |
| Points Scored: | 21.00 | 30.61 | 9.61 |
| Points Allowed: | 27.54 | 27.07 | 0.47 |
| Margin: | -6.54 | 3.54 | 10.08 |
| Total Points: | 48.54 | 57.68 | -9.14 |